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Awards of LIFEx



Unicancer 2020 award, 6th edition


link of unicancer

Aim of the project:
Our project is to develop an application that will enable the evaluation, in a multicenter, of radiomic or AI models proposed for the management of lung cancer patients. Multicenter validation of models remains indeed essential to consider their clinical use.

This application will actually be a new module added to LIFEx, a software we are developing, to easily describe a radiomic model. As for any module of this application, the libraries used will guarantee that the application remains free and autonomous (i.e. without installation of third party software). Interfacing with the ConSoRe platform, which is a Unicancer's Big Data platform, will later make it possible to combine features extracted from medical images and text included in the medical reports.

The main benefit will be to give medical teams a tool to evaluate radiomic and AI models on their own data, using models that have already been published or developed by colleagues. This large-scale, multicenter validation step provides information on the reliability and robustness of the models and is absolutely essential for clinical translation.

Problem to be solved:
If the field of radiomics and AI in radiology and nuclear medicine is growing exponentially, the current major bottleneck is the difficulty to validate the many published models in order to establish their performance and clinical added value. Our project will make this evaluation possible in an independent way, via a public software guaranteeing the transparency of the results.

Target users:
Our project will serve both the current users of LIFEx (10 Unicancer centers already use LIFEx, the 3600 users worldwide, including more than 700 in France) and future LIFEx users, given that we have about 100 new users every month. These are mainly radiologists, nuclear physicians, researchers and engineers involved in medical image analysis.


Read more: Awards of LIFEx

Libraries and licenses used

To view the LIFEx license: License

The libraries used by LIFEx and included in the package are as follows (you do NOT have anything to install except the single LIFEx package):

Latest version

The latest version is version 7.1.0



**************** LIFEx public version 7.1.0 *****************
What has been added, changed or updated in this new release?
Here is a list of the most significant additions, changes or updates in LIFEx v7.1.0:

- added: GML and GML1 units on TEP series
- added: arguments (script, image, directory) on command line
- added: display header of all loaded dicom files (and not only the first file)
- added: protocol box size reduced after five minutes
- improved: display of images and ROIs
- improved: the dialog boxes for protocols not used for 5 minutes are automatically minimized as an icon
- changed: save MIP 360° is mp4 format with rotation of 2°
- fixed issue: no freeze when mouse move out of MIP frame while recording MIP in MPEG4 format
- fixed issue: rtstruct.dcm save

Main (ROI):
- fixed issue: reading of some RTStruct DICOM that could not be read properly before
- fixed issue: nifti multi-ROI file with IOP and large number of ROIs (>100)
- fixed issue: contrast-based segmentation method
- fixed issue: RTStruct with image orientation in patient coordinate (IOP)
- fixed issue: clickDraw and clickDraw40% sometimes frozen
- fixed issue: colour mixing of overlaid ROIs
- fixed issue: on pencil2D, Nesle, Threshold tools

Texture protocol:
- removed: button of ROI check for texture
- added: correlation map on local map texture
- removed: comment of peakSphere1mL and 0.5mL Columns in texture result file
- fixed issue: suppression of the +1 in the discretization values only for values > maxBound

Quality Control protocol:
- add CT transverse
- add PT PSF

**************** LIFEx public version 7.0.0 *****************
What has been added, changed or updated in this new release?
Here is a list of the most notable additions, changes or updates in LIFEx v7.0.0:
Main: - added: addition of a shortcut for the settings in the protocol frame
- added: keyboard shortcut "P" to print the current view
- improved: optimized use of the RAM for histogram calculation (series and ROI)
- improved: change from jdk-8 to jdk-16 which integrates the new java modules (jmod)
- improved: support of 4K, 5K, 8K display resolution
- improved: generation of the iconography (SVG->PNG) is done only once at the first start of the application.
- improved: add .deb (debian, ubuntu) .rpm (fedora, redhat) .aarch64 (M1 mac) packaging of LIFEx distribution
- changed: documentation and tutorials are now excluded from the application and become exclusively accessible through Internet
- changed: resources, log, properties, setting files are moved into .LIFExv.v.v directory of root user
- fixed issue: bad filename on some written nifti file Main (Series):
- added: Fat (W500 L-100) window leveling of CT contrast
- added: Laplacian, Mean, Law, Wavelet series filters
- improved: read series from NRRD file format
- improved: Not a Number (NaN) values are no longer visible now (with aplha=0) on images
- improved: DICOM-RealWorldValueSlope file no longer stops the opening of the other series on loading
- fixed issue: empty sub region on US DICOM format are not copied on b-mode base image
- fixed issue: CT DICOM images with bitsAllocated=16, bitsStored=16, highBit=15
- fixed issue: DICOM multi frames with enhanced class storage and without PerFrameFunctionalGroupsSequence) / FrameContentSequence / DimensionIndexValues
- fixed issue: "Radionuclide Total Dose" DICOM attribute is now in MBq for NM modality, and in Bq for PET modality
- fixed issue: acquisition time instead of serieTime is displayed on overlaid images
- fixed issue: patient size are now in "float" value while it was "int" before (impact scale factor SuvLbm)
- fixed issue: no interpolation needed when matrix loaded from nifti are exact inversion (-1) on Z, Y or X axis (only flip is executed)
- fixed issue: add IOP management on registration file (DICOM-REG) Main (ROI):
- added: invert selection tool of ROI
- improved: read ROI from NRRD file format
- improved: new formatting of statistics in ROI box information
- improved: changed default names of ROI "C1...Cn" into new names "R1...Rn"
- downgrade: ROI file format before v4.00 is no longer supported
- fixed issue: KeepOne ROI tool on large matrix
Texture protocol:
- improved: all results of features are set to NaN when they are not selected for calculation
- improved: CONV/DISCRETIZED_peak (0.5mL and 1mL) are accelerated (on 2D slices only)
- fixed issue: DISCRETIZED_HISTO_Skewness is removed (duplicate values with DISCRETIZED_Skewness)
- fixed issue: DISCRETIZED_HISTO_Kurtosis is removed (duplicate values with DISCRETIZED_Kurtosis
- fixed issue: DISCRETIZED_HISTO_Entropy_log2 and__log10 are corrected
- fixed issue: DISCRETIZED_HISTO_Energy is corrected
- fixed issue: unavailable 3d processing on GUI on 2D series MTV protocol:
- added: Dmax (and other MTV features) feature is now available
- added (MTVNotation): add property "LIFEx.mtv.Frame.Annotation" to hide/show annotations ; none as default ; available options: none || fill
- added (MTVnotation): unvalid button on GUI
- changed (MTVnotation): minimal value of initial threshold is set to SUV 1.1
- changed (MTVnotation): empty ROI is now possible
- changed (MTVnotation): on result csv file, coordinate of SUVmax of selected ROI is written in place of mouse coordinate when clicking on ROI
- improved: greatly increased responsiveness when many ROIs are present
- improved: row of total results in csv file is now at the right place (right shift of one column)
- improved: add Center of mass(COM), sumBindCOM, avBindCOM, stdBindCOM, minBindCOM, maxBindCOM, avTotBindCOM on protocol
- fixed issue: no ROI creation if empty size PT Compartmental analysis protocol:
- added: dicom-extension in nifti file from PMOD1 format of extension (Frame Start Times & Frame Duration)
- added: added the width of the "frame duration" on the dynamic chart
- added: added a weighting corresponding to the "duration frame" in the TAC output file in dft format
- improved: "frame acquisition time" is replaced by "frame reference time" on dft file
- improved: x and y units are adjustable before saving on dft file Quality Control protocol:
- changed: rename of column title of field RedExternDiameterRatio by RedExternDiameter(mm) ; idem for GreenDiameterRatio and RedDiameterRatio


**************** LIFEx public version 6.30 *****************
What has been added, changed or updated in this new release? Here is a list of the most notable additions, changes or updates in LIFEx v6.30: -fixed issue: the display bug when translating an ROI - fixed issue: "image position (patient) (IPP)" on nifti ROI file - fixed issue: scale of ROI histogram - fixed issue: time on MR dynamic images with "trigger time" DICOM field - fixed issue (Labeling protocol): properties frame set to "Always On Top" - fixed on display: The exposure expressed in mAs (and not in mA as before) in CT images - fixed on display: The exposure in CT images is slice dependent (and not the same for all slices as before) - added: byte format in tiff image - added on display: peak kilo voltage output of the X-Ray generator used for CT images - improved: faster loading of images - improved: quick access to planar slice orientation directly on images - improved: quick access to Y units (intensity, ...) and X units (time) settings directly on images - improved: color change of text overlay on image (green text corresponds to settings that can be changed, while orange text shows settings that cannot be modified) - improved: series tools are redefined - improved: title "Edit" and "Tool" of ROI tools are now changed into "Create" and "Edit"
**************** LIFEx public version 6.20 *****************
version 6.20 - Fri Jui 9 19pm CEST 2020 What's been added, changed or updated in this new release? Here's a list of the most notable additions, changes or updates in LIFEx v6.20 - added: Series merger tool - added: writing of DICOM-RTStruct is available to save ROI - added: internal frames in application ; by default, all application frames are now gathered in a single frame. The separated frame format can still be set using the parameter settings menu - added: Sag alone layout template - added: Cor alone layout template - added: Laplacian of Gaussian image filter supported - added (Texture protocol): availability of Laplacian of Gaussian filter before calculation - added (Texture protocol): availability of Laplacian of Gaussian filter in texture script - added (MTV protocol): addition of new ZYX spacing of series in xls file result - fixed issue (Texture protocol): "Sorry, but no ROI is defined. Please define an ROI and start again" in texture scripts - improved: properties file is now in xml format to support Russian characters - improved: selected time frame of timing series for MIP display is available (and not fixed only at time 0) - improved: opening multi-modalities dicom (example:CT + RT-STRUCT + RT-DOSE) in the same directory automatically creates their corresponding DICOMDIR - deleted: all vertical layout protocols



**************** LIFEx public version 6.00 *****************
version 6.00 - Fri Mai 14 11am CEST 2020 What's new in (feature release) LIFEx 6.00? - fixed issue: message ['AcquisitionDateTime' is not defined. SUV may be incorrect.] is shown only if modality is PT or MN - fixed issue: minimal selection ROI is one voxel for circle3D or circle2D - fixed issue: multiple acquisitionNumber in one study - fixed issue: additional display frames are now decorated frames (including title bar for moving frame) - fixed issue: erroneous volume of ROI when Image Orientation Patient of ROI file was not identity - fixed issue: application of orientation volume when loading from DICOMDIR - fixed issue (Dsc-MR protocol): increase of the time range in which the peak following injection is looked for (#20 vs #4) - fixed issue (MTV protocol): clear values MTV, SMTV, TLG, STGL (in title menu of MTV protocol) when all ROI are cleared at the same time - fixed issue (Texture protocol): value of SHAPE_sphericity feature and SHAPE_compacity feature included in csv file result - fixed issue (Texture protocol): rename former HISTO_Skewness feature into CONV_Skewness feature - fixed issue (Texture protocol): rename former HISTO_Kurtosis feature into CONV_Kurtosis feature - fixed issue (Texture protocol): add new features: HISTO_Skewness, HISTO_Kurtosis - fixed issue (Texture protocol): add new features: DISCRETIZED_min, DISCRETIZED_mean, DISCRETIZED_std, DISCRETIZED_max, - fixed issue (Texture protocol): add new features: DISCRETIZED_Q1, DISCRETIZED_Q2, DISCRETIZED_Q3 - fixed issue (Texture protocol): add new features: DISCRETIZED_Skewness, DISCRETIZED_Kurtosis, DISCRETIZED_ExcessKurtosis - fixed issue (Texture protocol): add new features: DISCRETIZED_peakSphere0.5mL, DISCRETIZED_peakSphere1mL - fixed issue (Texture protocol): add new features: DISCRETIZED_TLG(mL) [onlyForPETorNM] - fixed issue (Texture protocol): add new features: DISCRETIZED_RIM_min, DISCRETIZED_RIM_mean, DISCRETIZED_RIM_stdev, DISCRETIZED_RIM_max, DISCRETIZED_RIM_sum - fixed issue (Texture protocol): increase of the robustness of feature values calculated from TexGLZLM matrix - fixed issue (Texture protocol): computation of SUVpeak and SUVstdev made more efficient, no changes in values - fixed issue (Texture protocol): quintic Lagrangian method used for spatial resampling does not affect min and max values anymore - fixed issue (Texture protocol): check button accounts for spatial resampling - added: quick orientation (Axial, Coronal, Sagittal) is available in each frame - added: automatic removal of CT patient table - added: display only border of ROI with border/fill button added to ROI tool menu (apply on all tools) - added: CoorMaxROI, COM and weightedCOM (wCOM) are saved in xls and csv export files - added: remove drawing (right button of mouse) when (absolute/relative) filter is activated - added: implementation of DICOM-REG (registration file between 2 series) - added: implementation of DICOM-RT Dose Module - added: implementation of loading/saving (3D and 4D) series in enhanced dicom format (Enhanced ClassStorage) - added: shadow on location crosshair to enhance visibility - added: implementation of spatial resampling series - added: implementation of decoder for Philips DICOM (JP2) images - added (DSC-MR protocol): echo time (TE) in description of nifti file - added (DSC-MR protocol): scripting dsc-mr calculations - added (Texture protocol): SHAPE_surface index in csv result file - added (Texture protocol): new dialog box to select ROI among those stored in an RTStruct file. - added (Texture protocol): 2D or 3D processing setting - added (Texture protocol): 4D or temporal 3D of local texture (Map) is available - added (Texture protocol): 2D processing of GLCM features in coronal and sagittal views - added (Texture protocol): add "calcium quantitation - Agatston score" feature for CT only - added (Labeling protocol): new protocol, labeling data of medical imaging protocol - added (Calcium protocol): new protocol, calcium quantitation - Agatston score for CT images - improved: 3D or 2D selection ROI: selecting a single voxel is possible - improved: add seriesNumber to the name of the directory where the ROI are saved - improved: list of protocols is now on a single frame (and not integrated under series gui) - improved: memory gain on the design of the application - improved: nifti ROI can be floating numbers (cast in integer ROI is implemented) - improved: RStruct volumes are consistent with RTStruct volume of MIM software - improved: diameter of circle3D and circle2D tools is displayed when tool size is changed - improved (DSC-MR protocol): TriggerTime dicom tag is taken into account if it exists - improved (Texture protocol): "sessionXls" is changed into "SessionCsv" (sensitive case) in script files - improved (Texture protocol): result file is changed to *.csv instead of *.xls (too many problems with excel files) - improved (Texture protocol): "check ROI for texture" is moved from ROI tools to Texture GUI - improved (Texture protocol): checking the voxels number compatible with textural feature calculations (64 for 3D ROI, 16 for 2D ROI) has moved after voxel resampling - improved (Texture protocol): processing of GLZLM and SUVpeak is faster - improved (Texture protocol): remove all hash and space characters in column title of csv ouput file - improved (Texture protocol): "NaN" values in result file when cluster is too small for textural feature calculation - improved (Texture protocol): the session result file has its name set automatically and fixed. It is created and appended automatically - improved (Texture protocol): time frame is calculated in texture calculation, time column is added to the result file - improved: if slices in RTStruct are not adjacent then interpolation between slices is performed - improved: color palette is now unique for each frame. Shift key down enables synchronization of all palettes when you modify it - changed tools: "Substract", "Undo" operations have been removed - changed tools: "Erode", "Dilate" operations systematically replace the existing ROI (instead of creating a new one)
**************** LIFEx public version 5.10 *****************
version 5.10 - Fri Jui 14 11am CEST 2019
What's new in (feature release) LIFEx 5.10?
- fixed (texture protocol): add a permanent message when file path of xls result file is wrong in a script file
- fixed (texture protocol): z rezampling (on 2D images) is set to 1 when z spacing value is less than current z spacing
- fixed (texture protocol): declare up to 4000 styles in a .xls workbook
- fixed (texture protocol): null results on all GLCM maps
- fixed cal_min and cal_max values on saved nifti file
- fixed IPP location on 4D nifti file format
- fixed nifti filename includes seriesDescription and title field
- fixed accuracy of values less than 10e-6 on ROI with main interface vs texture accuracy values je ne comprends pas
- fixed: some axial slices skipped on display when using wheel mouse navigation
- fixed: slices navigation using keyboard
- fixed: operation add,sub on series
- fixed: on some Siemens PET Dicom files, "Actual Frame Duration" dicom field empty can produce a wrong SUV conversion
- added: MIP processing with video card (largely increased performance)
- added: save in 4D nifti ormat
- added: multiple series management using scripts (see texture UserGuide for more information)
- added: substract, add,.. between times series is available
- added: LIFEx.Image.ImageOrientationPatient=true/false properties in properties file
- added: LIFEx.Image.ImagePositionPatient=true/false properties in properties file
- added (Dsc-MR protocol): add rCBF value in legend of ROI curve
- added (Dsc-MR protocol): add rCBF, rCBV, MTT, TTAB, and parameters of gamma function in ROI value display (and csv, xls)
- improved (texture protocol): increase in performance of CONV_peak calculation (4 times faster)
- improved (texture protocol): loading of all ROIs in directory when it is set on script line
- improved: loading PMOD format of ROI (voi)
**************** LIFEx public version 4.90 *****************
version 4.90 - Thue Apr 9 15pm CEST 2019
What's new in (feature release) LIFEx 4.90?
- added: header viewer of nifti format image
- added: ROI interpolation between two 2D ROI drawn on axial slices
- added: (texture protocol): quartile Q1, Q2 (median), Q3 in conventional indices
- added: loading 2D ROI in PNG, TIFF, BMP, GIF, JPG formats
- added: saving 3D image in nifti integer 16 bit signed (in addition to have nifti float 32 bit)
- added: unit of voxel size displayed on the image
- added: call of a texture script online directly in file (Linux OS only) (you can copy/paste the last command line with a different script file on each line)
- added: affine transform of series (S) with aS+b model
- changed: clik&draw and click40% tools now in the Tool menu
- changed: "draw" label menu is changed to "edit" label menu
- changed: the "move" tool selects the reference series automatically and avoids the corresponding warning message
- changed: decrease or increase of + -1 value by step wheel and Shift key pressed (and + -10 with Shift + Ctrl keys pressed at the same time) for snake2D and snake3D tools
- fixed (texture protocol): CONV_minvalue is now calculated
- fixed (MTV protocol): disabling of tools that not available on tool box option
- fixed (MTV protocol): ROI display on 360° angles of MIP
- fixed (MTV protocol): save custom values for pruning (initial & threshold steps) in preference session file
- fixed (MTV protocol): eye always open for maximum values in the sorting criterion menu
- fixed (MTV protocol): numerical sorting for sorting criterion with #id values
- fixed (MTV protocol): closing of the dialog box of sorting menu
- fixed (MTV protocol): artifactual ROI split visible on display
- fixed: rounded values of RTStruct contours are more accurate
- fixed: SUV conversion in Philips proprietary dicom format (formatted as a vector in uint8)
- fixed: round/floor of ROI location (on display) when using absolute or relative threshold
- fixed: threshold when SUV unit is selected
- fixed: optimisation of the memory management when running on Linux OS
**************** LIFEx public version 4.70 *****************
version 4.70 - Sat Feb 16 18pm CEST 2019
What's new in (feature release) LIFEx 4.70?
- fixed: slice thickness on Biograph_mMR (Siemens)
- fixed (texture protocol): RIM index: proper units (mL and #vx) assigned in excel file
- fixed (texture protocol): RIM index on some extreme anysotropic voxels
- fixed (texture protocol): RIM index on more than one ROI
- fixed: on mac only, wheel rotation is good direction when 2 finger shift on trackpad (downgrade on jdk1.8.0_144 version)
- thresholding at 40% (and by extension at n%) allowed on the time series. Note that the activated series and the activated time t are defined as reference for the calculation of the maximum value from which the 40% (respectively n% value) is calculated
- added: image number unit (in #) on X axis (in addition to have sec, min, h units)
- fixed: inopportune flash on MIP movie


**************** LIFEx public version 4.64 *****************
version 4.64 - Tue Feb 7 18pm CEST 2019
What's new in (feature release) LIFEx 4.64?
- updated: memory is better used when launching the application (linux all available memory without buff/cache is used)
- fixed: slice thickness on some CT scan


**************** LIFEx public version 4.62 *****************
version 4.62 - Monday Feb 4 10am CEST 2019
What's new in (feature release) LIFEx 4.62?
- fixed: change in the display of the cursor coordinates - fixed: sorting the series when more than one series is loaded (sorting criterion is « acquisition number » dicom field) - fixed (texture protocol): Automatic adjustment of relative/absolute intensity resampling menu as a function of the settings already filled


**************** LIFEx public version 4.60 *****************
version 4.60 - Wednesday Jan 30 07pm CEST 2019 What's new in LIFEx 4.60?
- added: save screenshot of MIP (png1))
- added: save screenshot of 360° of MIP view (png2)
- added: send screenshot of MIP to booklet (print)
- added: Dicom-REG (registration parameters) reading between two series with different StudyInstanceUID
- added: reading of images in tiff 16 bit format
- added: creation of a new parametric image from a dynamic series: mean of all times, time to peak, time to min, sum of all time images
- added: tissue save format file (dft) of Turku PET Center
- added: tissue save format file with recovery coefficient (dft+rc) of Turku PET Center
- added: Subtraction tool in ROI menu: create a new ROI by subtracting 2 visible ROI (ROI with open eye)
- added: Intersection tool in ROI menu: create a new ROI defined as the intersection of all visible ROI (ROI with open eye)
- added: loading of DICOM-SEG (segmentation parameters) as an ROI file
- added: new rainbow colormap
- added: new transparency on colormaps
- added: warning message when saving dcm files with IOP that are not identity matrix (not yet supported)
- added: Pixel Padding Value (0028,0120) DICOM field supported for CT
- added: possibility to remove the volume corresponding to a given time in a times series
- added: Click&Draw 40% tool added to ROI menu
- added: Dilation of the external edges of a ring ROI
- added: simple operation tools between images
- added: flip tools (R<>L, A<>P and I<>S) operating on images
- added: in linux version only: the available memory of the system is taken into account when launching LIFEx
- added: SUL units
- added: management of image orientation and position coordinates of patient when cor, sag, ax slices are displayed
- added: management of image orientation and position coordinates on viewer
- added: SUVpeak in 0.5mL volume in the result xls file.
- added: bounding box to define regions in which GLCM feature maps are calculated.
- added: Biograph mMR Dicom supported (SharedFunctionalGroupsSequence and PerFrameFunctionalGroupsSequence)
- added: reset all application parameters to default values
- added: software name and version in description tag of nifti ROI, images and MIP nifti written files
- added: warning message if ROI files already exist when a "save ROI" action is run
- added: Dicom screenshot (SOPClassUID) supported
- added: PixelPaddingValue (0028,0120) is used to identify pixels to be excluded from the normal grayscale rendering. It is now supported when reading images.
- added (texture protocol): Local texture map calculation for GLCM indices
- added (texture protocol): PARAMS_BinSize in result xls file
- added (texture protocol): possibility to define bin size value only, without the number of grey level values in the graphical user interface
- added (texture protocol): in the live activity report, (quick) display of the position of each roi while texture processing is on-going
- updated: display order of value voxel on top right of images is now in the same order than list of (layer) series
- updated: improved circle3D and circle2D drawing performance
- updated: crosshair coordinates in image space
- updated: checking and modification of default bound values as a function of the imaging modality for automatic tuning of the display.
- updated: improved loading performance of RTStruct coordinates with multithreading calculation of each z slice
- updated: loading (and also loading over network) now keeps images in data/temporary and not in /tmp in linux system
- updated: enabling of ImageOrientationPatient(iop) and ImagePositionPatient(ipp) when loading Dicom(dcm) et Nifti(nii) images
- updated: enabling of ImageOrientationPatient(iop) and ImagePositionPatient(ipp) when writing Nifti(nii) images
- updated: memory is better used when launching the application (linux all available memory is used, windows 95% of available memory is used, mac os is set to 3.5Go of RAM for 4Go version, 7Go of RAM for 8Go version and 15Go of RAM for 16Go version)
- updated: improvement of the selection of dropdown menus
- updated: MIP nifti file fully saved (before this correction: only every other view was saved)
- updated: "Restore" instead of "Undo" for restore last deleted ROI
- updated: discretization updated to agree with the image biomarker standardisation initiative (IBSI) description
- updated: speed improvement when drawing circle2D and circle3D tools
- updated (texture protocol): Z resampling disabled if 2D images are loaded
- updated (texture protocol): different management of the zero values in NGLDM matrices. Only NGLDM_Contrast and NGLDM_Busyness are affected
- updated (texture protocol): HISTO_kurtosis is shifted by a Fisher correction factor of -3 to have kurtosis equal to 0 for normal distributions
- updated (texture protocol): values expressed in scientific format in excel file results
- updated (texture protocol): discretization in agreement with the image biomarker standardisation initiative (IBSI) description
- updated (texture protocol): LIFEx.texture.SpatialResamplingZ has been changed to LIFEx.texture.ZSpatialResampling (same thing for Y and X) in script file
- updated (texture protocol): unit conversion problem (SUV, #, BqmL) of min and max discretization bounds (in some use cases) now fixed.
- fixed: fields radiopharmaceuticalStartTime and radionuclideTotalDose are set to 0 when reading nifti file
- fixed: automatic window/leveling apply to all modalities
- fixed: RT-Struct reading
- fixed: RT-Struct loading continues even if a ROI structure as no contour (empty ROI are not shown)
- fixed: SUV conversion in Philips proprietary dicom format
- fixed: add message in the web page of the user location map for Firefox navigator : "to view this content with Firefox, you must remove the tracking protection"
- fixed: min and max bounds of relative resampling (min, max, sd) are calculated only for the biggest cluster
- fixed: update of MTV volume when using click and click40% tools
- fixed: dilate/erode tools now work on 2D images
- fixed: update MIP view with use of snake2D and snake3D tools
- fixed: default size window of MIP
- fixed: DICOM-SEG from Olea with IOP and IPP
- fixed: IPP and IOP from DICOM image file with numberOfFrame>1
- fixed (texture protocol): the size of bin is now set to the value of bin size minus one (see the image biomarker standardisation initiative (IBSI) description)
- fixed (texture protocol): in advanced setting, GLZLM_SRE label is modified to GLZLM_SZE
- deleted: Empty button in ROI tools (the « dispose » button does the same)


**************** LIFEx public version 4.00 *****************
version 4.00 - Mon Apr 23 12:00:00 CEST 2018
What's new in LIFEx 4.00?
- save dynamic series in DICOM format
- directory in which data are saved can be changed by the user in preference frame
- maps of GLCM features are now available
- "diagnosis protocol" has been renamed "Viewer protocol"
- increase in performance when calculating Texture GLCM matrix
Major bug fixes:
- patient position corrected in dynamic time-series
Minor bug fixes:
- correction of timing value (msec) of the last time point in dynamic series
- correction of min and max value units in graph
- MTV: click & draw tool action now updates the MTV value
- hide circle2D and circle3D when mouse cursor exits frame


*************** LIFEx public version 3.74 *****************
version 3.74 - Mon Mar 19 11:00:00 CEST 2018
What's new in (feature release) LIFEx 3.74?
- renaming TMTV protocol into MTV protocol
- creation of a DICOMDIR when more than 2 directories are loaded simultaneously, if that file does not exist
- adding of seriesDescription, studydescription and PatientBirthDate dicom tag of a DICOMDIR file
- saving dicom (+anonymised) series in local disk
- nifti ROI loading allows loading multi value ROI in the same ROI file
Major bug fixes:
- sometimes, z shift of 1 voxel on ROI when loading RTSTRUCT file
- fixed artifacts when there were more than 1 contour sequence by slice in RTSTRUCT files
Minor bug fixes:
- now, release annoucement frame is not a modal frame
- texture: improved management in script execution when binSize=0 and nbGreyLevel=0
- texture: NGLDM_Busyness formula has now an absolute value at the denominator
- loading of coronal DIXON MR images with more than one contrast in the same series
- loading nifti-1 file when imagePositionPatient is not null
- texture: inversion in output xls file (optional) between rows and columns of the grey-level zone length matrix (GLZLM)
- improved tuning of the size of the menu windows as a function of the screen resolution and size


****************************** LIFEx public version 3.64 ***********************************

What's new in LIFEx 3.64?
- addition of translation of image layers with respect to the locked reference layer
- ending (and unselect tool) of ROI edition (circle2D, circle3D, Pensil2D) when pressing the "e" key on images
- texture: addition of parameter LIFEx.texture.GLCM.DistanceWithNeighbours=n in script file
- texture: text field of BinSize is now enabled when relative intensity resampling is selected
- addition of a message when the DICOM field studyInstanceUID of a new series that is loaded is not equal to the studyInstanceUID of the reference scan already loaded
- ROI move button is now enabled in tool manager on PT modality
- color of first ROI is now magenta (green before) for increased visibility
Major bug fixes:
- inversion Inf<->Sup on ROI when loading RT-Struct file
Minor bug fixes:
- TMTV protocol is now possible with series in NIFTI-1 (nii) format
- ROI creation is possible even after series in NIFTI format is loaded



****************************** LIFEx public version 3.56 *********************************** version 3.56 - Tue Jan 23 17:31:00 CEST 2018
What's new in LIFEx 3.56?
- loading of RT-Struct on reference layers other than LIFEx reference layers (first loaded series) is now available
- TMTV: addition of fast labelling of ROI with selection of names in a predefined list of names
- addition of a new protocol called "Diagnosis" corresponding to a simple viewer protocol without any complex functions
- addition of 6 new display options (template 1 to 6)
- Texture: CheckTex button is enabled only if texture protocol is selected
- Alphabetical sorting has been added to sort ROI layers
- AcquisitionNumber DICOM tag is now taken into account for the CT modality
- Addition of the coordinates (vx) of the voxel including the MaxValue within the ROI into ROI information
- Automatic setting of a default color map and alpha value to 0.5 when a second series is loaded
- Automatic setting of a default window/leveling based on the histogram of the loaded volume
- Creation and opening of a DICOMDIR file when 2 folders are loaded simultaneously, if that file does not exist.
- management of DICOM tag: imageRotation with an y inversion
Minor bug fixes
- Texture: the RT-STRUCT loading is now supported when using scripts
- TMTV: MIP ROI color is changed when ROI color is changed (dialog box of ROI)
- TMTV: existing MIP is fully loaded (while only every other angular views were loaded before)
- TMTV: % threshold is now in SUV "unit"
- Management (hide/show) button in ROI manager window
- Graph units now defined in the histogram image


****************************** LIFEx public version 3.42 *********************************** version 3.42 - Fri Dec 15 17:31:00 CEST 2017
What's in LIFEx 3.42?
- Texture: renaming of textural indices, e.g: Homogeneity of GLCM matrix become GLCM_Homogeneity
- Texture: increased precision of textural indice results (float->double)
- Texture: moving CONV_volume to SHAPE_volume in the xls results file
- Texture: absolute and relative resampling intensity also applies on first order indices (previously, relative resampling was systematically used for first order indices)
- Texture: new HISTO_entropy with log2 formula (HISTO_entropy_log2)
- Texture: new GLCM_entropy with log2 formula (GLCM_entropy_log2)
- Texture: new checkbox in advanced parameters of texture panel for saving values histogram in excel file
- Texture: when a ROI includes several clusters, the histogram is calculated using all cluster voxels while texture indices are calculated for the largest cluster only
- Main: removal of the validated/advanced levels in first windows (advanced is selected by default)
- Main: emoval of modalities choice (all modalities are selected by default)
Bug Fixes
- Texture: Correction of an edge effect in the GLCM
- TMTV: Liver value shown in the dialog box to set a threshold as a function of that value is now expressed in SUV units
- Main: modification of problematic slash into PatientID, PatientName, StudyDescription, SeriesDescription and SeriesUnit DICOM fields when saving image in nifti-1 file
- Main: reordering temporal images with the InstanceNumber field when the ImagesTime field is null on DICOM files


****************************** LIFEx public version 3.40 *********************************** version 3.40 - Thu Nov 09 11:30:00 CEST 2017
What's in LIFEx 3.40?
- improved memory management of the main application (mostly useful for running scripts)
- export of texture results in comma-separated values (csv) format file
- saving indices and texture parameters to be calculated from one work session to another
Bug Fixes
- random stalling of texture scripts
- long ROI name (>31 characters length) are now supported when saving results of texture protocol in an xls file
- default voxel distance for texture protocol is 1 vx (against 2 vx for the 3.38 version)


****************************** LIFEx public version 3.36 *********************************** version 3.36 - Thu Oct 26 18:30:00 CEST 2017
New software features:
- it's now possible to reorder layers of series to display them in any order
- error message is now displayed when texture input fields are not correctly defined
- fixed bug: error "The pixel size (x, y, z) of reference series must be smaller than the pixel size of selected series"
Miscellaneous, fixed and checked issues:
- the "null" value possibly assigned to the studyDescription DICOM field of the images no longer produces an error when saving nifti-1 file series
- restoring the view of "BirdEyeView" on Ax, Sag, Cor frame tools
- fixed bug: saving ROI in nifti-1 file series with proper "n+1" magic number in the header
- fonts and window size modified to adapt to low screen resolutions (<= 1280x1024 pixels)
- fixed bug: setting a ROI onto the 2D image with circle2D and snake2D tool
- new zoom cursor not as sensitive as before for easier handling.
- adding the fonts (bold, plain) on log file to debug


****************************** LIFEx public version 3.30 *********************************** version 3.30 - Wed Sep 20 11:39:00 CEST 2017
New software features:
- possible setting of the voxel size in which textural features are calculated in texture protocol
- management of multi-series with common ROI
File handling:
- PET images displayed in Bq/mL Units when conversion into SUV unit is not possible (missing Dicom fields)
- fixed bug: modification of problematic slash into PatientName DICOM field when saving results of texture protocol in an xls file
- fixed bug: oblique images now properly displayed when "orientation matrix » DICOM field is not null
Algorithms and utilities:
- refinement of the ROI position to calculate SUVpeak in PET: difference ≤ 0.01 between new SUVpeak compared to the one calculated in previous LIFEx regions
VOIs and paint:
- fixed bug: error in displaying ROI statistics when multi-series were loaded simultaneously
- fixed bug: Nestle ROI calculation was refined
- new tool: ROI erosion with defined voxels or spacing
- new tool: ROI dilation with defined voxels or spacing
- pencil2D tool: increased line width and added color at drag handle point. The Press "e" option was introduced to close (end handle point) ROI
Images and paint:
- change in maximum zoom factor of displayed image: images can be zoomed 4 times more
- addition of a low/high switch for quality rendering on images canvas with pressing the "s" key
- display of the position and value of the cursor for each loaded image series
- addition of a saving option (xls format) of the diplayed histogram values
- texture script are no longer stalled when a MIP view has been displayed
- removal of the empty row between title and values in the xls texture files
- addition of the SeriesDate field in the xls texture files
Miscellaneous, fixed and checked issues:
- correct setting of the ROI when displayed on an image series different from the one that was used to create the ROI
- cleaning a some stalled information messages
- UserGuide \ Nestle Segmentation, p.33: V (threshold) is changed into T (threshold) for clarity
- UserGuide \ tools GUI: Addition of the dilate/erode tools help
- AppendixTexture: Addition of the multi-series management



****************************** LIFEx public version 3.12 *********************************** version 3.12 - Fri Mon 26 15:00:00 CEST 2017
Major changes:
- new main features added in this version: no, minor version
VOIs and paint:
- fixed bug: after using the 2DSnake or 3DSnake tools, the displacement across slices using the (up, down) key was no longer exactly 1 voxel.
- fixed bug: drawing or loading ROI was impossible after reading nifti-1 file series



****************************** LIFEx public version 3.10 *********************************** version 3.10 - Jeu Jun 21 15:00:00 CEST 2017
Major changes:
- new main features added in this version: Maximum Intensity Projection (MIP)
Fixed issues:
- automatic calculation of textural features using scripts for multi-patients and multi-ROI / patient data (see documentation)
- new feature added in texture script: setting nbGreyLevels=0 for automatic calculation of the number of grey levels from the binSize parameter when relative discretization is used
- new feature added in texture script: setting binSize=0 for automatic calculation of the bin size from the nbGreyLevels parameter when relative discretization is used
- new feature added in texture script: loading of all script files at the same time (drag and drop) that will then be executed sequentially
- fixed bug in the erosion process
- fixed color coding when inverting the black and white colormap
- fixed ROI split tool to account for all voxels in the initial ROI.
File handling:
- a Philips DICOM bug found into old images that impacted SUV; (0x70531009 & rescaleSlope had identical value and scaling was performed twice in the conversion in SUV)
Algorithms and utilities:
- acceleration of ROI processing when multi layers of series are used
VOIs and paint:
- fixed "show/hide all ROI tool" when the button was used twice in a row.
- fixed update histogram and curve values when using the "show/hide button"
- improvement check tool "CheckTex" for good parameter ROI for texture processing (before script, it can be a step of validation) je ne comprends pas. En français ?
- add KeepOne tool for keep only the largest ROI (=split tool, with one ROI result)
- add Window/Leveling threshold ROI tool
- add fill3D ROI creation tool by filling "holes" in another ROI (example, lung fill) by clicking on a voxel within the hole that should be taken as the seed point.
- 3D and 2D snake tools are now available within all modalities, when multi-series have been loaded and for all protocols
- the reading of a ROI that has not been drawn on the loaded patient is now possible. The ROI shape is preserved but not the location in the image.
- texture documentation now includes explanation regarding the use of script for texture calculations


****************************** LIFEx public version 3.00 *********************************** version 3.00 - Fri Mar 17 15:00:00 CEST 2017
Major changes:
- new main features added in this version: MTV protocol
Fixed and verified issues:
File handling:
- Fixed and warning message concerning null value of SerieDate DICOM Field (0x00080021) need for SUV conversion
- Fixed and warning message concerning null value of SerieTime DICOM Field (0x00080031) need for SUV conversion
- Patient name is get and set from filename when loading a nifti (nii) files
Algorithms and utilities:
- New (total) Metabolic Tumor Volume Protocol as named : "MTV protocol"
- Improvements: MTV protocol - separatly of cluster in new ROIs after all thresholds
- Improvements: MTV protocol - viewing / editing of step1 calculation
- Improvements: Texture protocol - the distance of neighbours in GLCM is now available
- Improvements: Texture protocol - a new intensity range normalisation quantization method is available: resampling is performed in the range defined by mean+/-3sd of intensity values in the ROI
- Improvements: Texture protocol - date of processing (multi patient processing) is displaying in a new column and not in one line as before
VOIs and paint:
- Tool to measure angles is available on coronal and sagittal planes in addition to axial plane
- Tool to measure distances between two points (ruler) is available on coronal and sagittal planes in addition to axial plane
- Tool to pencil2D is available on coronal and sagittal planes in addition to axial plane
- Fixed minor bug in translate/snake2D/snake3D tools
- Fixed minor bug in circle2D/circle3D with multi ROIs overlapped
- Fixed loading nifti ROI files with no compression (.gz was already ok)
- New features: possible selection of several protocols in a single run
- Fixed: Open of advanced paramaters frame (Texture protocol)
- Fixed: Addition of warning message when no protocol selected in the first frame
- Fixed: New version available frame is now always on top of screen
- Improvements: addition of tutorial video of MTV protocol
- Fixed: Texture protocol documentation - formula to be used for the calculation of GLCM matrix corrected
- Add tutorial movies to learn MTV protocol



****************************** LIFEx public version 2.20 *********************************** version 2.20 - Thu Jan 17 10:54:00 CEST 2017
Important warnings:
- Following a modification of orientation in the recording and reading of ROIs stored in Nifti in LIFEX 2.20, all ROI files recorded using a previous version should be flipped in the left-right direction and in the anterior-posterior direction after being read
-- Flipping tools L<>R and A<>P are provided in the ROI toolbox
-- The flipped ROI should be saved so as to avoid having to repeat the flip operations each time the old ROI file is open
Network handling:
- Fixed: "No images found" error message when connecting to the DICOM server
File handling:
- Drag and drop image files from file system to series area of LIFEx
- Improvements: value -32768 on DICOM DataBufferShort detected an as error and set to 0
- Corresponding warning message in GUI: n voxels with value -32768 have been set to 0
- Improvements: reading/saving of images in Nifti-1 format (.nii) implement SUV and UH units (cf. filename)
- Fixed: directories and names of saved images (.img, .nii) are corrected on Windows OS
- Improvements of reading images in Nifti-1 format (.nii): Double and Float types are now supported
- Fixed: new Orientation of CT images in Nifi(nii) format files
- Fixed: ActualFrameDuration DICOM field can now be read with the scientific format (E+00)
- Removal of the preview of the "FileChooser" window which introduced a bug in windows10 and windows8
- Fixed: Orientation of the Patient Image in Dcm format images (Cor, Sag)
- No longer supported feature: the Analyse format file (.img+.hdr) is no longer supported
- Solved: FileChooser window random display using Windows10 and Windows8
Algorithms and utilities:
- Fixed a bug in relative resampling of Texture protocol (without impact on previous results)
- The TI of normalized GLCM calculated in each direction can be saved in a csv file
VOIs and paint:
- New tool for ROI sorting (as a function of SUVmean, SUVmax, Volume)
- New flip tools (existing R<>L, new A<>P and I<>S)
- Fixed Orientation Image in RT-Struct ROI
- Improvements: no load of ROI files on startup
- Improvements: Drag and drop ROI files from file system to ROI area of LIFEx
Image views and visualization:
- Optimization of images display (faster display)
- Fixed: a bug affecting the position of images tools on Mac OS
- Fixed: all temporary images are now deleted when exiting the application


****************************** LIFEx public version 2.00 *********************************** Tue Sep 13 15:42:00 CEST 2016
New Features:
- enhanced Graphical User Interface to facilitante the use of the software
- new positioning of some command buttons to make them compatible with the touchscreen feature of new laptop devices.
- reading of TIFF, JPEG, PNG, BMP image format
- reading/saving of images in Nifti (.nii) format
- new tool to measure angles
- new tool to measure distances between two points (ruler)
- reading of DICOM images in which many of the DICOM fields useful for nuclear medicine scans were removed (such as the DICOM "radiopharmaceuticalInformationSequence" including the radiopharmaceuticalStartTime, radionuclideTotalDose, radionuclideHalfLife fields)
- more flexible DICOM-RTStruct reading, with the possibility of reading files with a ReferencedSOPInstanceUID of the RTStruct files different from that of the loaded images
- the RTSTRUCT modality is active by default, so that regions can be read from external files without changing the default settings
- only two operating modes are now proposed: the "Validated" and "Advanced" modes
- automatic selection of the draw2D toll when creating an ROI from a 2D image
- checkbox for YES/NO output textural matrix files (no output by default)
- array transpose of result (Excel file)
Fixed bugs (or others):
- fonts and window size modified to adapt to HD screens (>= 3200x1800 pixels)
- documentation and tutorials updated to include the new graphic layout
- help messages associated with a tool remaining open when a new tool was selected are now removed
- deactivation of activated ROI-associated tools when an ROI is closed
- non closing of the browser used to read images when a patient folder is closed
- optimized pointer and line sizes as a function of the FOV of reference images
- "info DCM" tool inactivated when OTHER modalities are used (bmp, tif, jpg, png, gif, nii, img)
- 3D tools inactivated when 2D images are used
- create PDF of booklet is now located in patient/screensave/pdf directory (windows version only)
- error message "DICOM Tag location = 0 : ERROR" corrected on CT images
- JPGEG2000 Compression library on Windows operating system


****************************** LIFEx public version 1.83 *********************************** New Features:
- minor release, no new feature
- on request only (under password): calculation of K1, k2 and Ki using a 2 tissue-compartmental model (plasma + tissue)
- enhanced presentation of the conventional ROI metrics (mean, max, min, standard deviation)
- textural matrices now saved in cvs format in the file directory
Fixed bugs:
- closing of all windows when uploading data from a new patients without having to quit the application.


****************************** LIFEx public version 1.82 *********************************** New Features:
- minor release, no new feature
- Image (Lecture) :
- The "null" value possibly assigner to the SOPInstance DICOM field of the images no longer produces an error.
- The ImagePositionPatient DICOM field of the image series is accounted for when reading RT_STRUCT objects.
- Texture :
- The code for calculating the GLCM matrix has been parallelized.
- Textural parametres are saved from one session to another.
- The histogram is displayed for all ROIs in a same plot.
- ROI :
- Management of RTSTRUCT corresponding to images with a specific DICOM ImageOrientationPatient value.
- Management of the RT-STRUCT files when they are in the same directory as the associated images.
- Displacement of the 3D views based on the coordinates of the ROI maximum value when a layer is activated, so that the ROI is automatically visible in the display window.
- Simulatenous opening of several ROI (in nii format) using a single multiselection.
- Layers corresponding to intermediate ROI drawing steps in the Neste method are now deleted.
- The color of new ROI is now based on the color of existing ROI when the new ROI is derived from an existing one (for instance when using a copy or mirror operation).
- Display of the volume value (in cm3) when using the 2D disk and 3D disk segmentation tools.
Fixed bugs:
- correction of a message regarding cluster number > 1 on 2D slices and some 3D slices
- correction of the "Not a Number" error displayed when texture results were added in a "TextureSession.xls" session file
- position of the "curve" or "TAC" window now saved in the session preference.
- debug of the US reading for THOSHIBA TUS-A500 and SuperSonicImagine scanners.


****************************** LIFEx public version 1.8 *********************************** New Features:
- US b-mode modality is now implemented and fully supported for reading static/dynamic images.
- US Elastography of SuperSonicImagine is now implemented and fully supported for reading static images.
- US QualityMap of SuperSonicImagine is now implemented and fully supported for reading static images.
- Texture indices are calculated in a ROI for one or several layers (1 layer = 1 image series).
- no calculation of ROI TLG value when processing CT and MR images.
- no automatic ROI saved (to nifti format) if rename it.
- the use of a session file storing results obtained in several patients is now implemented.
- displaying float images with max values of 1.00 is now implemented (ex. US quality image).
- properties files now located in the user home directory.
- add a display window to choose the colormap of images series.
Corrected bugs:
- some DICOM-MOVE request errors have been fixed.


****************************** LIFEx public version 1.71 *********************************** Corrected bug:
- the 2D painting tool is available


****************************** LIFEx public version 1.7 ********************************** New Features:
- minor release, no new feature
- faster calculation of GLCM, NGLDM, Sphericity, Histogram-based index, and conventional index calculation using parallel threads.
- faster calculation of GLZLM using parallel threads (iLevel).
- faster calculation of GLRLM using parallel threads (iDirection).
- no calculation of ROI peak value when processing for CT and MR images.
- distribution of tar files instead of zip files to handle all execution permissions of files under linux
Corrected bugs:
- the "Radionuclide Total Dose" field is displayed only when its value is greater than 1 (Not in CT, MR images)
- the "Number of grey level" and "size of bins" values are now in integer format


****************************** LIFEx public version 1.65 *********************************** New Features:
- minor release, no new feature
- texture: the minimum number of grey levels is set to 1 (textural processing)
- optimization of the values displayed in the information box of ROI
- the diameter of the sphere used for the close operation is set to 20 mm instead of 10 voxels
- the threshold can be expressed as a range bound by a min and a max values in the ROI
Corrected bugs:
- extraction of multiple patients is implemented in a same DICOMDIR file
- after loading an RTSTRUCT object, calculation of the ROI size even when the ROI name of the RTSTRUCT object is null


******************************** LIFEx public version 1.6 ********************************** New Features:
- DICOM-RTSTRUCT is now implemented and fully supported for reading ROI only (not writing RTSTRUCT)
- DICOMDIR is now implemented and fully supported for reading DICOM images only (not writing DICOMDIR)
- threshold at n% of max value of ROI
- the dialog box now keeps in memory the path to the file that has been previously read.
- PT icon has been changed to a PET icon.
- verification of authorized operating level with RTSTRUCT modality activated or not
- new shortcut: when you click on the "Please select one or several imaging modality(ies)" header of the initial LIFEx menu, all modalities are activated.
- ScrollPane added on the panel serie of the main frame
- button of load RTSTRUCT added in the dialog box of ROI management
- button of load (analyse, nifti) ROI formats added in the dialog box of ROI management
- increase in performance calculations of the maximum values (SUVmax...)
- on windows version, setting of 95% of the free memory as the maximum memory busy from LIFEx.
Corrected bugs:
- offset correction of the 2D & 3D painting tool relative to the mouse cursor on thick slices with a high anisotropy of voxel.
- correction of message "The bin value is not defined or cannot be smaller than 5" for MR images.


******************************** LIFEx public version 1.5 ********************************** February 17th, 2016
- error in the version number on the Windows version.
- on windows version, setting of 80% of the free memory as the maximum memory busy from LIFEx.
- ScrollPane added on the panel series.


******************************** LIFEx public version 1.4 ********************************** February 17th, 2016
- WIN: transformed from 64B with the available memory to 3GB (now bigger CT and saving ROI are allowed).
- GUI: DcmBrowser -> GUI for editing "New Node" is added.
- GUI: DcmBrowser -> selecting one series from the network is added.
- TEX: reviewing textural inputs to add minimum bound for resampling CT scan.
- MAC: new release of version 1.3 is available.
- TEX: CT histogram with negative values is added.


******************************** LIFEx public version 1.3 ********************************** February 15th, 2016
- PRO: close button on window "Choose protocole" added.
- TEX: +abs(minValue) on CT texture matrix added.
- LIC: changes in section 13 of the license.
- MAIN: low memory display on load deleted.






THE COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FRENCH ATOMIC ENERGY AGENCY), a public scientific, technical and industrial establishment, having its registered office at 25 rue Leblanc – bâtiment le Ponant D – 75015 Paris cedex, hereinafter referred to as “CEA”, hereby licenses the right to use the LIFEx software as per the terms and conditions set out below.  

This license is granted to the natural or legal person – hereinafter the “Licensee” – having completed the application form and loaded the Software.

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Texture analysis is gaining considerable interest in medical imaging, in particular to identify parameters that might characterize tumor heterogeneity. We developed an easy-to-use freeware enabling calculation of a broad range of conventional, textural and shape indices from PET, MR, US and CT images.  

The software is written in Java and does not rely on any commercial libraries. LIFEx is dedicated to researchers, radiologists, nuclear medicine physicians and oncologists that giving access to 42 histogram, textural and shape indices in addition to conventional indices and where users can change calculation options (e.g. resampling method and number of grey levels for textural analysis).

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LIFEx Screenshots

This page shows a series of screenshots from our desktop program.


Slideshow navigation: click on a thumbnail to see the enlarged image.


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