**SHAPE_Sphericity** is how spherical a Volume of Interest is. Sphericity is equal to 1 for a perfect sphere.

\begin{equation}

SHAPE\_Sphericity=\frac{\pi^{1/3}\cdot(6V)^{2/3}}{A}

\end{equation}

where \(V\) and \(A\) correspond to the volume and the surface of the Volume Of Interest based on the Delaunay triangulation.

**SHAPE_Compacity** reflects how compact the Volume of Interest is.

\begin{equation}

SHAPE\_Compacity=\frac{A^{3/2}}{V}

\end{equation}

where \(V\) and \(A\) correspond to the volume and the surface of the Volume Of Interest based on the Delaunay triangulation.

**SHAPE_Volume** (mL and voxels) is the Volume of Interest in mL and in voxels.

\begin{equation}

SHAPE\_Volume=\sum_{i} V_i

\end{equation}

where \(V_i\) correspond to the volume of voxel \(i\) of the Volume Of Interest.